Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation

• Jingjing Wu,
• Hui Li and
• Song Cao

Beilstein J. Org. Chem. 2011, 7, 1070–1074, doi:10.3762/bjoc.7.123

• building block 2,2-difluoro-2-(phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile. Keywords: difluoromethyl functionality; gem-difluoromethylene-containing acid; pseudopeptides; reductive

• often drastically alters the chemical, physical, and biological properties of the parent compounds [6][7][8][9]. Nowadays, difluoromethyl-containing compounds are increasingly being applied in pharmaceuticals and agrochemicals [10][11][12]. It is reported that difluoromethyl functionality (CF2H) is